Alcohol Metabolism Lab

Our Programmes

Alcohol Metabolism and Genetics

Ever observed someone’s face turning red after drinking alcoholic beverages? This person is likely experiencing the Asian Flush syndrome. When alcohol enters our system, our body converts this alcohol into toxic acetaldehyde first before breaking it down further into a nontoxic compound. This is achieved by an enzyme in our body called Acetaldehyde Dehydrogenase (ALDH2).

However, some people have a variant of ALDH2 that is less effective in converting the toxic acetaldehyde into nontoxic compounds. Thus, causing a build up of acetaldehyde, leading to the dilation of blood vessels and the red flush. Acetaldehyde is known to be carcinogenic which damages DNA and increase the risk of cancer. This syndrome is most common in Asian people.

Curious about whether you have The Asian Flush Syndrome? Contact us to schedule a class!

Price: $183.12 per group (including GST)

Prices with effect from 1 Jan 2024

Program Details

Although students are too young to drink, this lab will give them a chance to identify whether if they have Acetaldehyde Dehydrogenase (ALDH2) Deficiency and be aware of their exposure to sources of acetaldehyde. Students will extract their own DNA from their cheek cells, perform PCR and gel electrophoresis to visualise the result.

Learning Outcomes

  • Micropipetting, DNA extraction, PCR and Gel electrophoresis.
  • Self DNA extraction
  • Understand the chemical breakdown of alcohol in our body through an enzyme call Acetaldehyde Dehydrogenase (ALDH2)

Total Estimated Time Period

180 mins

Difficulty Level

Advanced

Equipment Used

  • Micro-pipettes
  • miniPCR blueGel™ gel electrophoresis tank (part 2)
  • miniPCR mini8 thermocycler (part 2)